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IMMUNITY JOURNAL COVER + GRAPHICAL ABSTRACT

In 2022, I collaborated with an ophthalmology lab in at Harvard Medical School to produce a creative cover illustration and graphical abstract for Immunity journal. After lots of back-and-forth with the research team, and careful revisions, the final art was published on September 13, 2022.

Immunity journal cover. Sept. 13, 2022.
On the cover: The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer’s disease and a decreased risk of glaucoma. In this issue, Margeta et al. report that APOE-Galectin-3 signaling regulates cytotoxic neurodegenerative retinal microglia in glaucoma; the APOE4 allele attenuates microglial neurodegenerative phenotype, thus protecting neurons in glaucoma. Retinal microglia with the common APOE3 genotype (orange) become activated and cytotoxic and destroy nearby retinal neurons via Galectin-3 (sword). Microglia with the APOE4 genotype remain quiescent (blue-green), and the surrounding retinal neurons remain intact. Illustration by Fiona Martin.
Gallery Image
Graphical abstract: The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood. Margeta et al. demonstrate that APOE-Galectin-3 signaling regulates cytotoxic neurodegenerative retinal microglia in glaucoma and that the APOE4 allele attenuates microglial neurodegenerative phenotype and protects neurons in glaucoma. Illustration by Fiona Martin.

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